Polynucleotide Treatments

Naturally Regenerate, Repair & Rejuvenate Your Skin

At Avenue Medispa, we offer the latest generation of regenerative injectable treatments designed to improve skin quality from within. Polynucleotides are one of the most exciting advances in aesthetic medicine, stimulating your skin’s natural repair processes to restore hydration, elasticity and radiance without changing your natural facial features.

Unlike traditional dermal fillers, polynucleotides work by encouraging your body to regenerate healthy skin tissue. The result is smoother, firmer, healthier-looking skin that continues to improve over the weeks following treatment.

Our experienced medical practitioners offer three advanced treatments tailored to different concerns:

• PLINEST® – Skin regeneration for the face, neck and décolletage.
• PLINEST® Eye – Specifically formulated for the delicate eye area.
• Newest® – An innovative treatment combining polynucleotides with hyaluronic acid for enhanced skin hydration and rejuvenation.

What Are Polynucleotides?

Polynucleotides are highly purified DNA fragments that help stimulate the skin’s natural healing and regeneration processes. They encourage fibroblasts to produce new collagen and elastin, improve skin hydration and elasticity, reduce inflammation and protect cells from oxidative stress.

Rather than simply filling lines or adding volume, polynucleotides improve the overall health and quality of the skin, making them ideal for patients seeking natural-looking rejuvenation.

Benefits include:

• Improves skin texture and tone
• Stimulates collagen and elastin production
• Deeply hydrates the skin
• Reduces fine lines and crepey skin
• Improves skin firmness and elasticity
• Brightens tired, dull complexions
• Supports tissue repair
• Provides subtle, natural rejuvenation

PLINEST®

Regenerative Skin Rejuvenation

PLINEST® is an advanced injectable polynucleotide treatment designed to improve skin quality by stimulating natural tissue regeneration.

It is ideal for treating:

• Face
• Neck
• Décolletage
• Hands

PLINEST® is perfect for patients noticing early signs of ageing, loss of elasticity or dull, tired skin. Following treatment, collagen production increases gradually, leaving the skin smoother, firmer and healthier over the following weeks.

Ideal for treating:

• Fine lines
• Sun-damaged skin
• Loss of elasticity
• Rough skin texture
• Ageing skin
• Acne scarring

PLINEST® Eye

Targeted Rejuvenation for the Eye Area

The skin around the eyes is thinner and more delicate than anywhere else on the face, making it one of the first areas to show signs of ageing.

PLINEST® Eye has been specially developed to treat this delicate area by improving skin quality without adding unwanted volume.

It can help improve:

• Fine lines and crow’s feet
• Crepey eyelid skin
• Dark circles
• Thin, fragile skin
• Loss of firmness
• Tired-looking eyes

The result is brighter, smoother and more youthful-looking eyes with completely natural results.

Newest®

Polynucleotides Plus Hyaluronic Acid

Newest® combines the regenerative power of polynucleotides with the intense hydration provided by hyaluronic acid.

This dual-action treatment repairs skin while simultaneously restoring moisture levels, making it ideal for patients experiencing dehydrated, ageing or environmentally damaged skin.

Benefits include:

• Deep skin hydration
• Improved elasticity
• Increased collagen production
• Enhanced skin glow
• Smoother texture
• Reduction in fine lines
• Long-lasting skin rejuvenation

Newest® is particularly popular for patients wanting healthier, radiant skin with improved hydration and luminosity.

How Many Treatments Will I Need?

For optimal results we generally recommend:

• An initial course of 3 treatments
• Treatments spaced 2–4 weeks apart
• Maintenance treatments every 6–9 months depending on your skin concerns

Your practitioner will create a personalised treatment plan during your consultation.

Are Polynucleotides Right for Me?

Polynucleotide treatments are suitable for both men and women looking to improve skin quality naturally.

They are ideal if you want to:

• Prevent early signs of ageing
• Improve skin health
• Restore hydration
• Reduce fine lines
• Brighten tired skin
• Enhance your results alongside other aesthetic treatments

During your consultation, we’ll assess your skin and recommend the treatment most suitable for your concerns.